A volunteer home care worker, Nishima Rika (Megumi Okina), enters the home of a bed-ridden patient and discovers a strange ghostly presence lurking behind a door sealed with duct tape. Her discovery unleashes a horrible evil which baffles police investigators, who find that a whole series of people have gone missing from this particular house. Further investigation leads to Izutni Toyama (Misa Uehara), a former detective who handled the case of a man who murdered his wife in the house, but whose son was never found. But when the angry “Ju-On” spirit of vengeance that has infected the house reaches beyond its boundaries to kill Toyama and his daughter, Rika realizes that the horror is spreading.